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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731018 Species: Homo sapiens RGD Object: Gene Symbol: KDR Name: kinase insert domain receptor (a type III receptor tyrosine kinase)

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10836	6480464	CTD	2,3-bis(3'-hydroxybenzyl)butane-1,4-diol inhibits the reaction [Estradiol results in increased expression of KDR protein] 2,3-bis(3'-hydroxybenzyl)butyrolactone inhibits the reaction [Estradiol results in increased expression of KDR protein]	PMID:17289903
multiple interactions	EXP		6480464	CTD	[Estradiol results in increased secretion of VEGFA protein] which results in increased expression of KDR protein	PMID:17289903
increases expression	ISO	RGD:2965	6480464	CTD	Estradiol results in increased expression of KDR protein	PMID:9214597
increases expression	ISO	RGD:10836	6480464	CTD	Estradiol results in increased expression of KDR protein	PMID:17289903