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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428 Species: Rattus norvegicus RGD Object: Gene Symbol: Akr1c3 Name: aldo-keto reductase family 1, member C3

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1352888	6480464	CTD	[AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol	PMID:19010312
multiple interactions	ISO	RGD:1352888	6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of AKR1C3 mRNA	PMID:19619570
decreases expression	ISO	RGD:1352888	6480464	CTD	Estradiol results in decreased expression of AKR1C3 mRNA	PMID:19619570
multiple interactions	ISO	RGD:1352888	6480464	CTD	[AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol	PMID:20036328
decreases expression	ISO	RGD:1352888	6480464	CTD	Estradiol results in decreased expression of AKR1C3 mRNA	PMID:19619570 PMID:23019147