GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1b | affects expression | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | Estradiol affects the expression of CDKN1B mRNA | PMID:15598610 | Cdkn1b | decreases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Estradiol results in decreased expression of CDKN1B mRNA | PMID:22064387 | Cdkn1b | increases degradation | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Estradiol results in increased degradation of CDKN1B protein | PMID:17283133 | Cdkn1b | increases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Estradiol analog results in increased expression of CDKN1B protein | PMID:36460128 | Cdkn1b | increases expression | ISO | Cdkn1b (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of CDKN1B mRNA | PMID:17640349 | Cdkn1b | increases phosphorylation | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Estradiol results in increased phosphorylation of CDKN1B protein | PMID:23029392 | Cdkn1b | multiple interactions | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]; [Estradiol co-treated with Progesterone] results in increased expression of CDKN1B mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDKN1B protein; [Progesterone co-treated with Estradiol] results in increased expression of and results in increased stability of CDKN1B protein; Estradiol inhibits the reaction [Fenofibrate results in decreased expression of CDKN1B protein]; Estradiol promotes the reaction [Medroxyprogesterone Acetate results in increased expression of CDKN1B protein]; Estradiol results in decreased expression of and results in increased degradation of CDKN1B protein; Fulvestrant inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]; lactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]; MAPK1 protein affects the reaction [Estradiol results in increased phosphorylation of CDKN1B protein]; MAPK3 protein affects the reaction [Estradiol results in increased phosphorylation of CDKN1B protein]; Mifepristone inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CDKN1B protein]; SKP2 mutant form inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein] | PMID:17283133 PMID:22064387 PMID:23029392 PMID:29134746 PMID:9705214 | | ||||||||||||||||||||||
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