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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69057
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1i2
Name: nuclear receptor subfamily 1, group I, member 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1i2increases activityISONR1I2 (Homo sapiens)6480464CTDEstradiol results in increased activity of NR1I2 proteinPMID:15650019
Nr1i2multiple interactionsISONR1I2 (Homo sapiens)6480464CTDEstradiol binds to and results in increased activity of NR1I2 protein; Estradiol promotes the reaction [NR1I2 protein binds to MED1 protein]; Estradiol promotes the reaction [NR1I2 protein binds to NCOA1 protein]PMID:15650019 PMID:16054614 PMID:22223399
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