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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621081
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tgm2
Name: transglutaminase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgm2increases expressionEXP 6480464CTDEstradiol results in increased expression of TGM2 mRNAPMID:32145629
Tgm2multiple interactionsEXP 6480464CTD[bisphenol A co-treated with Estradiol] results in decreased expression of TGM2 mRNAPMID:26496021
Tgm2affects expressionISOTGM2 (Homo sapiens)6480464CTDEstradiol affects the expression of TGM2 mRNAPMID:14699072
Tgm2increases expressionISOTGM2 (Homo sapiens)6480464CTDEstradiol results in increased expression of TGM2 mRNAPMID:19619570 PMID:25321415 PMID:31614463
Tgm2increases expressionISOTgm2 (Mus musculus)6480464CTDEstradiol results in increased expression of TGM2 mRNAPMID:19484750
Tgm2multiple interactionsISOTGM2 (Homo sapiens)6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of TGM2 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of TGM2 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of TGM2 mRNA; ESR1 protein affects the reaction [Estradiol results in increased expression of TGM2 mRNA]PMID:14699072 PMID:17404688 PMID:19619570 PMID:30165855
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