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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620666
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map2k6decreases expressionISOMap2k6 (Mus musculus)6480464CTDEstradiol results in decreased expression of MAP2K6 mRNAPMID:25210133
Map2k6decreases expressionISOMAP2K6 (Homo sapiens)6480464CTDEstradiol results in decreased expression of MAP2K6 mRNAPMID:31614463
Map2k6multiple interactionsISOMap2k6 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in decreased expression of MAP2K6 mRNA]PMID:25210133
Map2k6multiple interactionsISOMAP2K6 (Homo sapiens)6480464CTD[Estradiol co-treated with TGFB1 protein] results in decreased expression of MAP2K6 mRNA; [Progesterone co-treated with Estradiol] results in increased expression of MAP2K6 mRNAPMID:17404688 PMID:30165855
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