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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620574 Species: Rattus norvegicus RGD Object: Gene Symbol: Cybb Name: cytochrome b-245, beta polypeptide

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1350492	6480464	CTD	Estradiol inhibits the reaction [AGT protein results in increased expression of CYBB mRNA] Estradiol inhibits the reaction [AGT protein results in increased expression of CYBB protein]	PMID:16097371
multiple interactions	EXP		6480464	CTD	[Medroxyprogesterone Acetate co-treated with Estradiol] results in increased expression of CYBB protein	PMID:21670166