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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620474
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sox9
Name: SRY-box transcription factor 9
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sox9affects expressionISOSOX9 (Homo sapiens)6480464CTDEstradiol affects the expression of SOX9 mRNAPMID:14699072
Sox9decreases expressionISOSOX9 (Homo sapiens)6480464CTDEstradiol results in decreased expression of SOX9 mRNAPMID:19167446 PMID:20106945
Sox9decreases expressionISOSox9 (Mus musculus)6480464CTDEstradiol results in decreased expression of SOX9 mRNAPMID:19484750
Sox9increases expressionISOSOX9 (Homo sapiens)6480464CTDEstradiol results in increased expression of SOX9 mRNAPMID:19619570
Sox9increases expressionISOSox9 (Mus musculus)6480464CTDEstradiol results in increased expression of SOX9 mRNAPMID:25210133
Sox9multiple interactionsISOSOX9 (Homo sapiens)6480464CTD[Arsenic co-treated with Estradiol] results in decreased expression of SOX9 mRNA; [Estradiol co-treated with EGF protein] results in increased expression of SOX9 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of SOX9 mRNA; [Estradiol co-treated with TGFB1 protein] results in increased expression of SOX9 mRNA; [Progesterone co-treated with Estradiol] results in decreased expression of SOX9 mRNAPMID:17404688 PMID:19619570 PMID:24758408 PMID:30165855 PMID:33047385
Sox9multiple interactionsISOSox9 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of SOX9 mRNA]PMID:25210133
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