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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDEstradiol results in decreased expression of ERBB2 mRNA; Estradiol results in decreased expression of ERBB2 proteinPMID:15072547 PMID:16393665 PMID:16488535 PMID:26921789 PMID:31614463 PMID:31646340
Erbb2increases expressionISOErbb2 (Mus musculus)6480464CTDEstradiol results in increased expression of ERBB2 mRNAPMID:17640349
Erbb2increases expressionISOERBB2 (Homo sapiens)6480464CTDEstradiol results in increased expression of ERBB2 mRNAPMID:17555868
Erbb2multiple interactionsISOErbb2 (Mus musculus)6480464CTD[ERBB2 protein co-treated with ERBB3 protein] results in increased susceptibility to EstradiolPMID:19861407
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTD[Cycloheximide co-treated with Estradiol] results in decreased expression of ERBB2 mRNA; Estradiol promotes the reaction [Resveratrol results in increased expression of ERBB2 protein]; Fulvestrant inhibits the reaction [Estradiol results in decreased expression of ERBB2 mRNA]PMID:15072547 PMID:16488535 PMID:31646340
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