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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects expressionEXP 6480464CTDEstradiol affects the expression of CDK1 mRNAPMID:32145629
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDEstradiol results in decreased expression of CDK1 mRNAPMID:31646340
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDEstradiol results in increased expression of CDK1 mRNAPMID:16474171 PMID:18310284 PMID:19167446 PMID:22476901
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDEstradiol results in increased expression of CDK1 mRNAPMID:20826375 PMID:25210133
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTDRaloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]; trichostatin A inhibits the reaction [Estradiol results in increased expression of CDK1 mRNA]; trichostatin A inhibits the reaction [Raloxifene Hydrochloride promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]]PMID:22476901
Cdk1multiple interactionsISOCdk1 (Mus musculus)6480464CTDESR1 protein promotes the reaction [Estradiol results in increased expression of CDK1 mRNA]PMID:25210133
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