GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | affects expression | EXP | | 6480464 | CTD | Estradiol affects the expression of H2AX mRNA | PMID:32145629 | H2ax | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of H2AX protein | PMID:23788033 | H2ax | multiple interactions | EXP | | 6480464 | CTD | Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein] | PMID:23788033 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Estradiol results in increased expression of H2AX mRNA; Estradiol results in increased expression of H2AX protein; Estradiol results in increased expression of H2AX protein modified form | PMID:16462019 PMID:16474171 PMID:19167446 PMID:25933419 PMID:31939680 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Estradiol results in increased expression of H2AX protein modified form | PMID:31939680 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Estradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form] | PMID:26148434 PMID:31939680 | |
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