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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axaffects expressionEXP 6480464CTDEstradiol affects the expression of H2AX mRNAPMID:32145629
H2axincreases expressionEXP 6480464CTDEstradiol results in increased expression of H2AX proteinPMID:23788033
H2axmultiple interactionsEXP 6480464CTDFulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein]PMID:23788033
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDEstradiol results in increased expression of H2AX mRNA; Estradiol results in increased expression of H2AX protein; Estradiol results in increased expression of H2AX protein modified formPMID:16462019 PMID:16474171 PMID:19167446 PMID:25933419 PMID:31939680
H2axincreases expressionISOH2ax (Mus musculus)6480464CTDEstradiol results in increased expression of H2AX protein modified formPMID:31939680
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDEstradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AX protein]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of H2AX protein modified form]PMID:26148434 PMID:31939680
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