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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353194 Species: Homo sapiens RGD Object: Gene Symbol: CXCR1 Name: chemokine (C-X-C motif) receptor 1

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Estradiol affects the expression of CXCR1 protein Estradiol affects the expression of CXCR1 mRNA	PMID:19401270
multiple interactions	EXP		6480464	CTD	[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of CXCR1 protein	PMID:16517565
decreases expression	EXP		6480464	CTD	Estradiol results in decreased expression of CXCR1 protein	PMID:16517565