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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346266 Species: Homo sapiens RGD Object: Gene Symbol: FAS Name: Fas (TNF receptor superfamily, member 6)

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:1552455	6480464	CTD	Estradiol results in increased expression of FAS mRNA	PMID:18359623
increases mutagenesis	EXP		6480464	CTD	Estradiol results in increased mutagenesis of FAS gene	PMID:19139166
decreases expression	EXP		6480464	CTD	Estradiol results in decreased expression of FAS mRNA	PMID:23019147