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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323522 Species: Homo sapiens RGD Object: Gene Symbol: NRIP1 Name: nuclear receptor interacting protein 1

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	EXP		6480464	CTD	Estradiol affects the expression of NRIP1 mRNA	PMID:14699072
affects expression	ISO	RGD:1323523	6480464	CTD	Estradiol affects the expression of NRIP1 mRNA	PMID:15598610
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:17555868 PMID:15757668 PMID:16029874
multiple interactions	ISO	RGD:1311850	6480464	CTD	[Estradiol co-treated with ormeloxifene] promotes the reaction [NRIP1 protein binds to ESR1 protein]	PMID:19460436
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:16029874 PMID:17555868 PMID:15757668
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:15757668 PMID:17555868 PMID:16029874
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:15757668 PMID:16029874 PMID:17555868
multiple interactions	EXP		6480464	CTD	AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TFF1 promoter]] AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]] ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TFF1 promoter]] ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]] Estradiol promotes the reaction [ESR1 protein binds to AHR protein binds to NRIP1 protein] Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TFF1 promoter] Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TSKU promoter] Estradiol promotes the reaction [NRIP1 protein binds to CYP1B1 promoter] [Estradiol promotes the reaction [NRIP1 protein binds to TFF1 promoter]] which results in decreased expression of TFF1 mRNA [Estradiol promotes the reaction [NRIP1 protein binds to HSPB8 promoter]] which results in decreased expression of HSPB8 mRNA [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]] which results in decreased expression of TSKU mRNA	PMID:22071320
affects response to substance	EXP		6480464	CTD	NRIP1 protein affects the susceptibility to Estradiol	PMID:22071320
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:15757668 PMID:16029874 PMID:17555868 PMID:22989670
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NRIP1 mRNA	PMID:15757668 PMID:16029874 PMID:17555868 PMID:22989670 PMID:23019147
multiple interactions	EXP		6480464	CTD	[Estradiol binds to ESR2 protein] which results in increased expression of NRIP1 mRNA	PMID:20404318