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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313354 Species: Homo sapiens RGD Object: Gene Symbol: NKX3-1 Name: NK3 homeobox 1

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	AR protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA] ESR2 protein affects the reaction [Estradiol results in increased expression of NKX3-1 mRNA] fulvestrant inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA] PD 98059 inhibits the reaction [Estradiol results in increased expression of NKX3-1 mRNA]	PMID:17131305
increases expression	EXP		6480464	CTD	Estradiol results in increased expression of NKX3-1 mRNA	PMID:17131305