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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1303089
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsn
Name: gelsolin
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsnaffects expressionEXP 6480464CTDEstradiol affects the expression of GSN mRNAPMID:32145629
Gsnaffects expressionISOGSN (Homo sapiens)6480464CTDEstradiol affects the expression of GSN mRNAPMID:22574217
Gsnmultiple interactionsISOGSN (Homo sapiens)6480464CTD[Estradiol results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; Estradiol inhibits the reaction [ESR1 protein binds to GSN protein]PMID:22403704 PMID:29389661
Gsnmultiple interactionsISOGsn (Mus musculus)6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of GSN mRNAPMID:18556351
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