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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10116 Species: Mus musculus RGD Object: Gene Symbol: Afp Name: alpha fetoprotein

Acc ID: CHEBI:16469 Term: 17beta-estradiol Definition: The 17beta-isomer of estradiol. CasRN: 50-28-2 Chemical ID: MESH:D004958

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:736278	6480464	CTD	[Estradiol co-treated with Progesterone] results in increased expression of AFP protein	PMID:18497072
multiple interactions	ISO	RGD:2065	6480464	CTD	Diethylstilbestrol inhibits the reaction [Estradiol binds to AFP protein]	PMID:9748407
affects binding	ISO	RGD:2065	6480464	CTD	Estradiol binds to AFP protein	PMID:9748407
increases response to substance	EXP		6480464	CTD	AFP protein results in increased susceptibility to Estradiol	PMID:22720075
affects binding	ISO	RGD:2065	6480464	CTD	Estradiol binds to AFP protein	PMID:23013281 PMID:9748407