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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621747
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsr
Name: glutathione-disulfide reductase
Acc ID: CHEBI:16433
Term: trans-caffeic acid
Definition: The trans-isomer of caffeic acid.
Chemical ID: MESH:C040048
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrmultiple interactionsEXP 6480464CTDcaffeic acid inhibits the reaction [Cisplatin results in decreased activity of GSR protein]PMID:21640567
Gsrmultiple interactionsISOGSR (Homo sapiens)6480464CTDcaffeic acid promotes the reaction [Thapsigargin results in decreased expression of GSR mRNA]PMID:19442820
Gsrmultiple interactionsISOGsr (Mus musculus)6480464CTDcaffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [GSR protein results in increased oxidation of NADP]]; caffeic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of GSR protein]PMID:22036979
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