Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 631408
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp8
Name: matrix metallopeptidase 8
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp8increases expressionISOMMP8 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of MMP8 mRNAPMID:18625914
Mmp8multiple interactionsISOMMP8 (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine affects the susceptibility to Lipopolysaccharides] which results in increased expression of MMP8 mRNA; [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of MMP8 mRNA; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP8 mRNA]PMID:18625914 PMID:35811015
Go Back to source page   Continue to Ontology report