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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621808
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Park7
Name: Parkinsonism associated deglycase
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Park7affects localizationISOPark7 (Mus musculus)6480464CTDLipopolysaccharides affects the localization of PARK7 proteinPMID:19063952
Park7increases expressionISOPark7 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of PARK7 proteinPMID:11811539
Park7multiple interactionsISOPark7 (Mus musculus)6480464CTDdiphenyleneiodonium inhibits the reaction [Lipopolysaccharides results in increased expression of PARK7 protein]; PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]; PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of Dinoprostone]]; SB 203580 promotes the reaction [PARK7 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]PMID:11811539 PMID:26691871
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