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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621238
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tnfrsf1b
Name: TNF receptor superfamily member 1B
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1bdecreases expressionISOTnfrsf1b (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of TNFRSF1B proteinPMID:37177863
Tnfrsf1bincreases expressionISOTNFRSF1B (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of TNFRSF1B proteinPMID:10072544
Tnfrsf1bincreases expressionISOTnfrsf1b (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of TNFRSF1B mRNA; Lipopolysaccharides results in increased expression of TNFRSF1B proteinPMID:10975854 PMID:19133137 PMID:22169119 PMID:25890327 PMID:26582142
Tnfrsf1bmultiple interactionsISOTNFRSF1B (Homo sapiens)6480464CTD[Acetaminophen co-treated with Lipopolysaccharides] results in increased expression of TNFRSF1B mRNA; NFKBIA protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B protein]PMID:10072544 PMID:31059760
Tnfrsf1bmultiple interactionsISOTnfrsf1b (Mus musculus)6480464CTD(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]; [IL10 protein co-treated with Dexamethasone] inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; IL10 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; procyanidin B3 inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B mRNA]; terameprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1B protein]; TLR4 protein affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TNFRSF1A protein affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]; TNFRSF1A protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in decreased expression of TNFRSF1B protein]]PMID:19133137 PMID:22169119 PMID:25890327 PMID:37177863
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