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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619930
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb11
Name: ATP binding cassette subfamily B member 11
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb11decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of ABCB11 mRNA; Lipopolysaccharides results in decreased expression of ABCB11 proteinPMID:12795754 PMID:15205389
Abcb11multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Isoniazid] results in decreased expression of ABCB11 mRNA; Lipopolysaccharides affects the localization of and results in decreased expression of ABCB11 proteinPMID:12706339 PMID:25331106
Abcb11affects expressionISOAbcb11 (Mus musculus)6480464CTDLipopolysaccharides affects the expression of ABCB11 proteinPMID:15778272
Abcb11decreases expressionISOABCB11 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of ABCB11 proteinPMID:15205115
Abcb11decreases expressionISOAbcb11 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of ABCB11 mRNAPMID:15312235 PMID:15313196 PMID:15778272 PMID:30633930
Abcb11multiple interactionsISOAbcb11 (Mus musculus)6480464CTD[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein; obeticholic acid inhibits the reaction [[triptolide co-treated with Lipopolysaccharides] results in decreased expression of ABCB11 protein]PMID:36328986
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