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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3932
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp2
Name: uncoupling protein 2
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp2multiple interactionsISOUcp2 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA; Sodium Selenite inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of UCP2 mRNA]; UCP2 protein promotes the reaction [Carbon Monoxide inhibits the reaction [Lipopolysaccharides results in increased expression of EGR1 protein]]PMID:15650415 PMID:22046279
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