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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3772
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Stat3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat3increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of STAT3 proteinPMID:35279615
Stat3increases phosphorylationEXP 6480464CTDLipopolysaccharides results in increased phosphorylation of STAT3 proteinPMID:12584205
Stat3multiple interactionsEXP 6480464CTD15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; loganin inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of STAT3 protein]; Rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]PMID:12584205 PMID:35279615
Stat3increases activityISOStat3 (Mus musculus)6480464CTD[Lipopolysaccharides results in increased activity of JAK2 protein] which results in increased activity of STAT3 protein; Lipopolysaccharides results in increased activity of STAT3 proteinPMID:21586572 PMID:21595956 PMID:22118570 PMID:24486434
Stat3increases activityISOSTAT3 (Homo sapiens)6480464CTDLipopolysaccharides results in increased activity of STAT3 proteinPMID:21586572
Stat3increases expressionISOStat3 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of STAT3 mRNAPMID:10975854 PMID:17321000 PMID:26582142
Stat3increases phosphorylationISOStat3 (Mus musculus)6480464CTDLipopolysaccharides results in increased phosphorylation of STAT3 proteinPMID:21262334 PMID:21595956 PMID:22083490 PMID:22155741 PMID:22225513 PMID:23370008 PMID:25576658 PMID:29470957 PMID:30053449
Stat3increases phosphorylationISOSTAT3 (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of STAT3 proteinPMID:32583487 PMID:37209277
Stat3increases response to substanceISOStat3 (Mus musculus)6480464CTDSTAT3 gene mutant form results in increased susceptibility to Lipopolysaccharides; STAT3 results in increased susceptibility to LipopolysaccharidesPMID:15781265 PMID:25429137
Stat3multiple interactionsISOStat3 (Mus musculus)6480464CTD[Curcumin binds to 4-bis(2-chloroethyl)aminobenzaldehyde] inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein]; [Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein; chlorophyllin inhibits the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; cirsimarin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; IFNAR1 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; IL10 protein affects the reaction [Resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; kaempferol 7-O-glucoside inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein; Lipopolysaccharides results in increased phosphorylation of and affects the localization of STAT3 protein; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein; loganin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein]; lycorine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; MAPKAPK3 protein affects the reaction [MAPKAPK2 protein affects the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]]; Melatonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; morroniside inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased phosphorylation of STAT3 protein]; praeruptorin C inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; praeruptorin E inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with TLR4] results in increased phosphorylation of STAT3 protein]; Resveratrol inhibits the reaction [Lipopolysaccharides results in increased activity of STAT3 protein]; Resveratrol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]; STAT3 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; withaferin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein]PMID:16275627 PMID:21396905 PMID:21586572 PMID:22083490 PMID:22118570 PMID:22155741 PMID:22225513 PMID:24095726 PMID:25576658 PMID:29470957 PMID:30053449 PMID:33617879 PMID:35279615
Stat3multiple interactionsISOSTAT3 (Homo sapiens)6480464CTD[Nicotine co-treated with Lipopolysaccharides] results in increased phosphorylation of STAT3 protein; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide promotes the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]; daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of STAT3 protein; MIR152 mRNA affects the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]; REG3A protein inhibits the reaction [daphnetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]]PMID:21135123 PMID:21606497 PMID:32583487 PMID:37209277
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