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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3342
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plat
Name: plasminogen activator, tissue type
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Platincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of PLAT proteinPMID:27098997
Platmultiple interactionsEXP 6480464CTDPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of PLAT protein]PMID:27098997
Platincreases expressionISOPLAT (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of PLAT mRNAPMID:35811015
Platmultiple interactionsISOPlat (Mus musculus)6480464CTD[[Lipopolysaccharides binds to and results in increased activity of TLR4 protein] which co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PLAT mRNAPMID:21097750
Platmultiple interactionsISOPLAT (Homo sapiens)6480464CTD[S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of PLAT mRNA; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in increased expression of PLAT mRNA]PMID:35811015
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