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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3318
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcb1b
Name: ATP-binding cassette, sub-family B member 1B
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcb1bincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of ABCB1B mRNAPMID:11779202 PMID:15205389
Abcb1bmultiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of ABCB1B mRNA]; Lipopolysaccharides promotes the reaction [TNF protein results in increased expression of ABCB1B mRNA]PMID:15205389 PMID:20300455
Abcb1baffects expressionISOAbcb1b (Mus musculus)6480464CTDLipopolysaccharides affects the expression of ABCB1B mRNA; Lipopolysaccharides affects the expression of ABCB1B proteinPMID:15778272
Abcb1bmultiple interactionsISOAbcb1b (Mus musculus)6480464CTDLipopolysaccharides affects the reaction [ABCB1B protein results in increased secretion of Doxorubicin]PMID:15778272
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