Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2868
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Igf1
Name: insulin-like growth factor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Igf1decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of IGF1 proteinPMID:16522730 PMID:31486215
Igf1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of IGF1 mRNA; Lipopolysaccharides results in increased expression of IGF1 proteinPMID:16448778
Igf1multiple interactionsEXP 6480464CTD[Lipopolysaccharides co-treated with Rutin] results in decreased expression of IGF1 mRNA; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]; Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]; Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 mRNA]; Tretinoin inhibits the reaction [Lipopolysaccharides results in increased expression of IGF1 protein]PMID:16448778 PMID:16522730 PMID:28693884 PMID:31486215
Igf1increases expressionISOIGF1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of IGF1 mRNAPMID:35953652
Igf1multiple interactionsISOIgf1 (Mus musculus)6480464CTD[IGF1 protein co-treated with Lipopolysaccharides] results in decreased expression of TLR4 mRNA; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL1B mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of IL6 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TLR4 mRNA]; [picropodophyllin co-treated with Lipopolysaccharides] inhibits the reaction [IGF1 protein results in decreased expression of TNF mRNA]; IGF1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; IGF1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; IGF1 protein inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]PMID:21371294
Igf1multiple interactionsISOIGF1 (Homo sapiens)6480464CTD[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of IGF1 proteinPMID:18437699
Go Back to source page   Continue to Ontology report