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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2806
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmox1
Name: heme oxygenase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmox1decreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of HMOX1 proteinPMID:26497626 PMID:27224288 PMID:29480285 PMID:37148149
Hmox1increases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of HMOX1 mRNA; Lipopolysaccharides results in increased expression of HMOX1 proteinPMID:16415329 PMID:20519841 PMID:25436953 PMID:25715797 PMID:27830717 PMID:28881715
Hmox1multiple interactionsEXP 6480464CTD17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [[Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA] which results in increased chemical synthesis of Bilirubin; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [Dimethyl Sulfoxide co-treated with Resveratrol] inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; [Galactosamine co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Hydrogen Peroxide co-treated with Ammonium Sulfate] promotes the reaction [[Lipopolysaccharides co-treated with IFNG] results in increased expression of HMOX1]; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with IFNG] results in increased expression of HMOX1; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; butaprost promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; butaprost promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; gossypin inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; Hemin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Probucol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Resveratrol inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [Hemin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]PMID:15035594 PMID:16415329 PMID:18073186 PMID:19796704 PMID:21401295 PMID:25436953 PMID:25715797 PMID:26497626 PMID:27224288 PMID:27830717 PMID:28881715 PMID:29480285 PMID:37148149
Hmox1affects expressionISOHmox1 (Mus musculus)6480464CTDLipopolysaccharides affects the expression of HMOX1 proteinPMID:23000425
Hmox1decreases expressionISOHmox1 (Mus musculus)6480464CTDLipopolysaccharides results in decreased expression of HMOX1 proteinPMID:26363199 PMID:36169195 PMID:37436358
Hmox1decreases expressionISOHMOX1 (Homo sapiens)6480464CTDLipopolysaccharides results in decreased expression of HMOX1 mRNA; Lipopolysaccharides results in decreased expression of HMOX1 proteinPMID:26497626 PMID:35811015 PMID:36135333 PMID:37436358
Hmox1increases activityISOHmox1 (Mus musculus)6480464CTDLipopolysaccharides results in increased activity of HMOX1 proteinPMID:24003391
Hmox1increases expressionISOHmox1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of HMOX1 mRNA; Lipopolysaccharides results in increased expression of HMOX1 proteinPMID:20861358 PMID:21355878 PMID:22080918 PMID:22169119 PMID:23000425 PMID:23352929 PMID:23962744 PMID:24003391 PMID:24095726 PMID:25171655 PMID:26505893 PMID:27339419 PMID:27751938 PMID:30635848 PMID:32187984 PMID:33049506 PMID:34029560
Hmox1increases expressionISOHMOX1 (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of HMOX1; Lipopolysaccharides results in increased expression of HMOX1 mRNAPMID:22000456 PMID:24001438
Hmox1multiple interactionsISOHmox1 (Mus musculus)6480464CTD17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; 17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]; 8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which affects the localization of RELA protein; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased abundance of Superoxides; [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein] which results in increased phosphorylation of NFKBIA protein; [chromium mesoporphyrin inhibits the reaction [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]] which results in increased expression of HMOX1 protein; [cobaltiprotoporphyrin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; [Curcumin inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] which results in increased expression of HMOX1 protein; [Dust co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Eicosapentaenoic Acid co-treated with procyanidin B3] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; [Industrial Waste co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Inorganic Chemicals co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with 1-dodecylsulfonyl-5N,6O-oxomethylidenenojirimycin] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] affects the expression of HMOX1 protein; [Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with N-bromotaurine] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with N-chlorotaurine] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Quercetin] results in increased expression of HMOX1 protein; [NFE2L2 protein results in increased expression of HMOX1] affects the reaction [alpha-viniferin results in decreased susceptibility to Lipopolysaccharides]; [Organic Chemicals co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Particulate Matter co-treated with Lipopolysaccharides] results in increased expression of HMOX1 mRNA; [Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; [sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; [tricarbonyldichlororuthenium (II) dimer co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein; [zinc protoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of HMOX1 protein]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; copper protoporphyrin IX promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Dinoprostone inhibits the reaction [copper protoporphyrin IX promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Eicosapentaenoic Acid promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Ethanol promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Fluoxetine inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Hemin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]; Hemin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]; HMOX1 protein affects the reaction [Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of CXCL10 mRNA]; HMOX1 protein inhibits the reaction [[Lipopolysaccharides results in increased activity of TLR4 protein] which results in increased expression of IFNB1 mRNA]; HMOX1 protein inhibits the reaction [Dimethyl Fumarate inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Nitrites]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]; HMOX1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; HMOX1 protein inhibits the reaction [Probucol inhibits the reaction [Lipopolysaccharides results in increased abundance of Dinoprostone]]; HMOX1 protein promotes the reaction [3-hydroxyflavone inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; HMOX1 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]; HMOX1 protein promotes the reaction [ADIPOQ protein inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]]; HMOX1 protein promotes the reaction [baicalein inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; HMOX1 protein promotes the reaction [kaempferol inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; HMOX1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]; HMOX1 protein promotes the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]; HMOX1 protein promotes the reaction [MAPK9 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNF protein]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HMOX1 protein promotes the reaction [Nicotine inhibits the reaction [Lipopolysaccharides results in increased expression of ZFP36 mRNA]]; HMOX1 protein promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; HMOX1 protein promotes the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Lipopolysaccharides promotes the reaction [Indirubin E804 results in increased expression of HMOX1 mRNA]; luteolin-7-O-glucuronide promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; maytenonic acid promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; maytenonic acid promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; morroniside promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; palmatine inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Plant Extracts promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Plant Extracts promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; Quercetin promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; S Ht31 promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]; Saponins inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; SB 203580 inhibits the reaction [17-hydroxyjolkinolide B promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; Silymarin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]; Silymarin promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]; sodium arsenite promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; STAT3 protein promotes the reaction [[Lipopolysaccharides co-treated with Nicotine] results in increased expression of HMOX1 mRNA]; TLR4 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 mRNA]]; zinc protoporphyrin inhibits the reaction [8-oxoberberine promotes the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [[Lipopolysaccharides co-treated with 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone] results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[Simvastatin co-treated with Lipopolysaccharides] results in increased expression of HMOX1 protein]; zinc protoporphyrin inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]PMID:14563492 PMID:15309569 PMID:17973899 PMID:18073186 PMID:19376148 PMID:19667931 PMID:20861358 PMID:21444764 PMID:21925249 PMID:22080918 PMID:22169119 PMID:23000425 PMID:23107598 PMID:23352929 PMID:23735482 PMID:23942037 PMID:24003391 PMID:24095726 PMID:24859013 PMID:25171655 PMID:26363199 PMID:26505893 PMID:27523796 PMID:27751938 PMID:29191728 PMID:29689377 PMID:30635848 PMID:32187984 PMID:32339640 PMID:33049506 PMID:34029560 PMID:35691465 PMID:36169195 PMID:37436358
Hmox1multiple interactionsISOHMOX1 (Homo sapiens)6480464CTD6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]; [cobaltiprotoporphyrin results in increased activity of HMOX1 protein] promotes the reaction [[Lipopolysaccharides co-treated with CSF1 protein] results in increased expression of IL10 protein]; [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein; [Lipopolysaccharides co-treated with IFNG protein] promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HMOX1 mRNA]; [Lipopolysaccharides co-treated with IFNG protein] results in increased expression of HMOX1 mRNA; [Lipopolysaccharides co-treated with Resveratrol] results in increased expression of HMOX1 protein; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL1B protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of IL6 protein]]; [tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in decreased susceptibility to [surfactin peptide results in decreased susceptibility to [Lipopolysaccharides results in increased secretion of TNF protein]]; catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Cobalt promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of HMOX1 mRNA]; gingerenone A inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; HMOX1 mutant form inhibits the reaction [Cilostazol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; HMOX1 mutant form inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; HMOX1 protein affects the reaction [alloin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Lipopolysaccharides promotes the reaction [Nickel results in increased expression of HMOX1 protein]; Luteolin promotes the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of HMOX1 protein]; NFE2L2 gene mutant form inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]; Organometallic Compounds promotes the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of HMOX1 mRNA]; PIK 75 inhibits the reaction [[Lipopolysaccharides co-treated with Resveratrol] results in increased expression of HMOX1 protein]; Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]; S-(1,2-dichlorovinyl)cysteine inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 mRNA]; SIRT1 protein affects the reaction [catalpol inhibits the reaction [Lipopolysaccharides results in decreased expression of HMOX1 protein]]PMID:20131233 PMID:20580464 PMID:20833156 PMID:22173130 PMID:23788629 PMID:24001438 PMID:26497626 PMID:30768972 PMID:30769049 PMID:34217685 PMID:35811015 PMID:36135333 PMID:37436358
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