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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61888 Species: Rattus norvegicus RGD Object: Gene Symbol: Map2k2 Name: mitogen activated protein kinase kinase 2

Acc ID: CHEBI:16356 Term: 3',5'-cyclic GMP Definition: A guanyl ribonucleotide that has formula C10H12N5O7P. CasRN: 7665-99-8 Chemical ID: MESH:D006152

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:1343460	6480464	CTD	Cyclic GMP results in decreased phosphorylation of MAP2K2 protein	PMID:18225537
multiple interactions	ISO	RGD:1343460	6480464	CTD	Cyclic GMP affects the reaction [NPPA protein alternative form results in decreased phosphorylation of and results in decreased activity of MAP2K2 protein]	PMID:18225537