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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621241 Species: Rattus norvegicus RGD Object: Gene Symbol: Adamts1 Name: ADAM metallopeptidase with thrombospondin type 1 motif, 1

Acc ID: CHEBI:16330 Term: 17beta-hydroxy-5alpha-androstan-3-one Definition: An androgen that has formula C19H30O2. CasRN: 521-18-6 Chemical ID: MESH:D013196

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:736845	6480464	CTD	Dihydrotestosterone results in increased expression of ADAMTS1 protein Dihydrotestosterone results in increased expression of ADAMTS1 mRNA	PMID:17018655
multiple interactions	ISO	RGD:736845	6480464	CTD	Estradiol inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 mRNA] hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 mRNA] hydroxyflutamide inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 protein] Estradiol inhibits the reaction [Dihydrotestosterone results in increased expression of ADAMTS1 protein] [Progesterone co-treated with Dihydrotestosterone] results in increased expression of ADAMTS1 mRNA [Progesterone co-treated with Dihydrotestosterone] results in increased expression of ADAMTS1 protein	PMID:17018655