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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:16330
Term: 17beta-hydroxy-5alpha-androstan-3-one
Definition: A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.
Chemical ID: MESH:D013196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects bindingISOAHR (Homo sapiens)6480464CTDDihydrotestosterone binds to AHR proteinPMID:20436506
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDAHR protein inhibits the reaction [[FHL2 protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; AHR protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]; Dihydrotestosterone inhibits the reaction [6-methyl-1,3,8-trichlorodibenzofuran results in increased activity of AHR protein]; FHL2 protein inhibits the reaction [AHR protein promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]]PMID:15026081 PMID:19815066
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