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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70884
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Eif2ak3
Name: eukaryotic translation initiation factor 2 alpha kinase 3
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Eif2ak3multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [cypermethrin results in increased expression of EIF2AK3 mRNA]; Quercetin inhibits the reaction [Vincristine results in increased expression of EIF2AK3 mRNA]PMID:33038355 PMID:35876585
Eif2ak3increases phosphorylationISOEIF2AK3 (Homo sapiens)6480464CTDQuercetin results in increased phosphorylation of EIF2AK3 proteinPMID:24368982 PMID:24612139
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