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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3684
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc11a2
Name: solute carrier family 11 member 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc11a2decreases expressionEXP 6480464CTDQuercetin results in decreased expression of SLC11A2 mRNAPMID:25058155
Slc11a2decreases expressionISOSLC11A2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of SLC11A2 mRNAPMID:21632981
Slc11a2multiple interactionsISOSlc11a2 (Mus musculus)6480464CTDQuercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [[Ethanol co-treated with Iron] results in increased expression of SLC11A2 protein]; Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [Ethanol results in increased expression of SLC11A2 protein]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 mRNA]; Quercetin inhibits the reaction [Iron results in increased expression of SLC11A2 protein]PMID:24569067
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