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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3439
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ptgs1
Name: prostaglandin-endoperoxide synthase 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ptgs1decreases expressionEXP 6480464CTDQuercetin results in decreased expression of PTGS1 mRNAPMID:19056647
Ptgs1decreases activityISOPTGS1 (Homo sapiens)6480464CTDQuercetin results in decreased activity of PTGS1 proteinPMID:15155531
Ptgs1increases expressionISOPTGS1 (Homo sapiens)6480464CTDQuercetin results in increased expression of PTGS1 mRNAPMID:22996356
Ptgs1multiple interactionsISOPTGS1 (Homo sapiens)6480464CTD[Quercetin co-treated with Paraquat] results in increased expression of PTGS1 mRNAPMID:22996356
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