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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3343
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plau
Name: plasminogen activator, urokinase
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Plauincreases expressionEXP 6480464CTDQuercetin results in increased expression of PLAU mRNAPMID:17478321
Plaudecreases expressionISOPLAU (Homo sapiens)6480464CTDQuercetin results in decreased expression of PLAU mRNA; Quercetin results in decreased expression of PLAU proteinPMID:21308698 PMID:23645742
Plauincreases expressionISOPLAU (Homo sapiens)6480464CTDQuercetin results in increased expression of PLAU mRNA; Quercetin results in increased expression of PLAU proteinPMID:11236827 PMID:12724357
Plaumultiple interactionsISOPLAU (Homo sapiens)6480464CTDDactinomycin inhibits the reaction [Quercetin results in increased expression of PLAU mRNA]PMID:11236827
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