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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3001
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lepr
Name: leptin receptor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Leprmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Fructose results in increased expression of and results in increased phosphorylation of LEPR protein]PMID:22426011
Leprincreases expressionISOLEPR (Homo sapiens)6480464CTDQuercetin results in increased expression of LEPR mRNA; Quercetin results in increased expression of LEPR proteinPMID:22230496
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