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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2561
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Erbb2
Name: erb-b2 receptor tyrosine kinase 2
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Erbb2decreases expressionISOERBB2 (Homo sapiens)6480464CTDQuercetin results in decreased expression of ERBB2 proteinPMID:15741050
Erbb2decreases phosphorylationISOERBB2 (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of ERBB2 proteinPMID:18655187
Erbb2increases expressionISOERBB2 (Homo sapiens)6480464CTDQuercetin results in increased expression of ERBB2 mRNAPMID:14715546
Erbb2multiple interactionsISOERBB2 (Homo sapiens)6480464CTD[Deoxyglucose co-treated with Quercetin] results in increased ubiquitination of ERBB2 protein; [Glucose deficiency co-treated with Quercetin] results in increased ubiquitination of ERBB2 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Quercetin results in decreased expression of ERBB2 protein]; Deoxyglucose inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; ferrous sulfate inhibits the reaction [Quercetin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]; geldanamycin inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; Glucose deficiency inhibits the reaction [Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]]; Quercetin inhibits the reaction [EGF protein results in increased phosphorylation of ERBB2 protein]; Quercetin inhibits the reaction [TGFA protein results in increased phosphorylation of ERBB2 protein]; Quercetin promotes the reaction [ERBB2 protein binds to HSP90AA1 protein]; Quercetin promotes the reaction [geldanamycin results in decreased expression of and results in increased ubiquitination of ERBB2 protein]; Quercetin promotes the reaction [ST13 protein modified form binds to and results in increased ubiquitination of ERBB2 protein]; Quercetin results in decreased expression of and results in decreased phosphorylation of ERBB2 protein; ST13 protein modified form affects the reaction [Quercetin results in increased ubiquitination of ERBB2 protein]PMID:12888923 PMID:18655187
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