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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahraffects activityEXP 6480464CTDQuercetin affects the activity of AHR proteinPMID:19286049
Ahrdecreases expressionEXP 6480464CTDQuercetin results in decreased expression of AHR mRNAPMID:23281070
Ahrmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in increased expression of AHR mRNA]PMID:23281070
Ahraffects activityISOAHR (Homo sapiens)6480464CTDQuercetin affects the activity of AHR proteinPMID:19286049
Ahraffects bindingISOAHR (Homo sapiens)6480464CTDQuercetin binds to AHR proteinPMID:19299563
Ahraffects response to substanceISOAHR (Homo sapiens)6480464CTDAHR protein affects the susceptibility to QuercetinPMID:10359656
Ahrdecreases localizationISOAHR (Homo sapiens)6480464CTDQuercetin results in decreased localization of AHR proteinPMID:21756928
Ahrincreases activityISOAhr (Mus musculus)6480464CTDQuercetin results in increased activity of AHR proteinPMID:30203046
Ahrincreases activityISOAHR (Homo sapiens)6480464CTDQuercetin results in increased activity of AHR proteinPMID:19034627 PMID:19794518
Ahrincreases expressionISOAhr (Mus musculus)6480464CTDQuercetin results in increased expression of AHR mRNAPMID:22334599
Ahrincreases expressionISOAHR (Homo sapiens)6480464CTDQuercetin results in increased expression of AHR mRNAPMID:22422552
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDQuercetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]PMID:17869316
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTD[Quercetin co-treated with Methylcholanthrene] affects the activity of AHR protein; [Quercetin co-treated with Tetrachlorodibenzodioxin] affects the activity of AHR protein; AHR gene mutant form inhibits the reaction [Quercetin results in increased expression of CYP1A1 mRNA]; AHR gene mutant form inhibits the reaction [Quercetin results in increased expression of UGT1A1 mRNA]; AHR protein affects the reaction [Quercetin results in increased activity of CYP1A1 protein]; AHR protein promotes the reaction [Quercetin results in increased expression of ABCG2 protein]; Quercetin binds to and results in increased activity of AHR protein; Quercetin inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased localization of AHR protein]; Quercetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Quercetin promotes the reaction [AHR protein binds to CYP1A1 promoter]; Quercetin promotes the reaction [AHR protein binds to PON1 promoter]PMID:10359656 PMID:14644660 PMID:15169886 PMID:17077187 PMID:19286049 PMID:21756928 PMID:29584932
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