GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550709
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl10
Name: chemokine (C-X-C motif) ligand 10
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions.
CasRN: 117-39-5
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]

Quercetin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]

PMID:19426678
multiple interactionsISORGD:13520246480464CTDQuercetin inhibits the reaction [S100B protein results in increased expression of CXCL10 mRNA]

PMID:17103373
multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [TNF protein promotes the reaction [CREBBP protein binds to CXCL10 promoter]]

Quercetin inhibits the reaction [TNF protein results in increased expression of CXCL10 mRNA]

Quercetin inhibits the reaction [TNF protein promotes the reaction [RELA protein binds to CXCL10 promoter]]

PMID:17449583
decreases expressionISORGD:13520246480464CTDQuercetin results in decreased expression of CXCL10 mRNA

PMID:21756928
decreases secretionISORGD:13520246480464CTDQuercetin results in decreased secretion of CXCL10 protein

PMID:21756928
multiple interactionsISORGD:13520246480464CTDQuercetin inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased secretion of CXCL10 protein]

PMID:21756928
decreases expressionISORGD:13520246480464CTDQuercetin results in decreased expression of CXCL10 mRNA

PMID:21756928
PMID:21967610
decreases secretionISORGD:13520246480464CTDQuercetin results in decreased secretion of CXCL10 protein

PMID:21756928
PMID:21967610
multiple interactionsISORGD:13520246480464CTDQuercetin inhibits the reaction [PD168393 results in increased expression of CXCL10 mRNA]

Quercetin promotes the reaction [leptomycin B results in decreased secretion of CXCL10 protein]

PMID:21967610
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