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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347215 Species: Homo sapiens RGD Object: Gene Symbol: TIMP1 Name: TIMP metallopeptidase inhibitor 1

Acc ID: CHEBI:16243 Term: quercetin Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. CasRN: 117-39-5 Chemical ID: MESH:D011794

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Quercetin promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of TIMP1 mRNA] Quercetin promotes the reaction [Cholesterol, LDL results in increased expression of TIMP1 mRNA]	PMID:11414687
decreases expression	EXP		6480464	CTD	Quercetin results in decreased expression of TIMP1 mRNA Quercetin results in decreased expression of TIMP1 protein	PMID:11506819
increases expression	EXP		6480464	CTD	Quercetin results in increased expression of TIMP1 protein Quercetin results in increased expression of TIMP1 mRNA	PMID:11414687
increases expression	EXP		6480464	CTD	Quercetin results in increased expression of TIMP1 mRNA	PMID:11414687 PMID:21632981