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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628659
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nrxn1
Name: neurexin 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nrxn1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of NRXN1 proteinPMID:23178681
Nrxn1multiple interactionsEXP 6480464CTDHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 protein]PMID:23178681
Nrxn1decreases expressionISONRXN1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of NRXN1 mRNAPMID:27624276
Nrxn1increases methylationISONRXN1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased methylation of NRXN1 promoterPMID:27624276
Nrxn1multiple interactionsISONRXN1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; S-Adenosylmethionine inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]PMID:27624276
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