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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621625
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Aurkb
Name: aurora kinase B
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aurkbaffects localizationISOAURKB (Homo sapiens)6480464CTDHydrogen Peroxide affects the localization of AURKB proteinPMID:28343997
Aurkbdecreases expressionISOAURKB (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of AURKB mRNAPMID:12414654
Aurkbmultiple interactionsISOAURKB (Homo sapiens)6480464CTD[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of AURKB protein; Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein]; CAT protein inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein]PMID:18951874 PMID:28343997
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