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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620795
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Src
Name: SRC proto-oncogene, non-receptor tyrosine kinase
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srcdecreases phosphorylationEXP 6480464CTDHydrogen Peroxide results in decreased phosphorylation of SRC proteinPMID:23178681
Srcmultiple interactionsEXP 6480464CTDHyaluronic Acid analog inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of SRC protein]; Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]; PLD2 protein affects the reaction [Hydrogen Peroxide promotes the reaction [PTK2B protein binds to SRC protein]]PMID:15705590 PMID:23178681
Srcincreases activityISOSRC (Homo sapiens)6480464CTDHydrogen Peroxide results in increased activity of SRC proteinPMID:12902192
Srcmultiple interactionsISOSRC (Homo sapiens)6480464CTDHydrogen Peroxide inhibits the reaction [beta-methylcholine results in increased phosphorylation of SRC protein]PMID:21179406
Srcmultiple interactionsISOSrc (Mus musculus)6480464CTD[Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK1 protein; [Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK3 protein; HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK1 protein]; HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of SRC protein] which results in increased activity of MAPK3 protein]PMID:14975446
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