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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionEXP 6480464CTDHydrogen Peroxide affects the expression of NFE2L2 proteinPMID:34047419
Nfe2l2affects localizationEXP 6480464CTDHydrogen Peroxide affects the localization of NFE2L2 proteinPMID:24437944 PMID:31412289
Nfe2l2decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of NFE2L2 mRNA; Hydrogen Peroxide results in decreased expression of NFE2L2 protein; Hydrogen Peroxide results in decreased expression of NFE2L2 protein modified formPMID:29992723 PMID:36305173
Nfe2l2increases activityEXP 6480464CTDHydrogen Peroxide results in increased activity of NFE2L2 proteinPMID:22606287
Nfe2l2increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of NFE2L2 proteinPMID:22606287
Nfe2l2multiple interactionsEXP 6480464CTD[alpha-Tocopherol co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; [cyanidin 3-sambubioside co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; [echinacoside co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; [luteolin 5-O-glucopyranoside co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; [Rutin co-treated with Hydrogen Peroxide] affects the localization of NFE2L2 protein; [Thiazoles analog binds to indoline analog] inhibits the reaction [SESN2 protein promotes the reaction [Hydrogen Peroxide results in increased activity of NFE2L2 protein]]; Acetylcysteine promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; Hydrocortisone inhibits the reaction [Hydrogen Peroxide promotes the reaction [sulforaphane results in increased expression of NFE2L2 protein]]; Hydrogen Peroxide promotes the reaction [sulforaphane results in increased activity of NFE2L2 protein]; Hydrogen Peroxide promotes the reaction [sulforaphane results in increased expression of NFE2L2 protein]; Hydrogen Peroxide results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein; Hydrogen Peroxide results in increased expression of and affects the localization of NFE2L2 protein; KEAP1 protein inhibits the reaction [SESN2 protein promotes the reaction [Hydrogen Peroxide affects the localization of and results in increased activity of NFE2L2 protein]]; NFE2L2 protein affects the reaction [Exenatide inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Glucose results in increased secretion of INS1 protein]]]; NFE2L2 protein promotes the reaction [SIRT6 protein inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; notoginsenoside R1 promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; PLK2 protein affects the reaction [Hydrogen Peroxide affects the expression of NFE2L2 protein]; SESN2 protein promotes the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of and results in increased activity of NFE2L2 protein]; trilobatin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]PMID:22606287 PMID:24437944 PMID:27939242 PMID:30104959 PMID:30660577 PMID:31412289 PMID:32275923 PMID:34047419
Nfe2l2affects expressionISONFE2L2 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of NFE2L2 mRNA; Hydrogen Peroxide affects the expression of NFE2L2 proteinPMID:20044591 PMID:30703377
Nfe2l2affects expressionISONfe2l2 (Mus musculus)6480464CTDHydrogen Peroxide affects the expression of NFE2L2 proteinPMID:36356655
Nfe2l2affects localizationISONFE2L2 (Homo sapiens)6480464CTDHydrogen Peroxide affects the localization of NFE2L2 proteinPMID:32980322 PMID:34077701 PMID:36058301
Nfe2l2affects response to substanceISONfe2l2 (Mus musculus)6480464CTD[NFE2L2 affects the susceptibility to sulforaphane] which affects the susceptibility to Hydrogen PeroxidePMID:19303893
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of NFE2L2 mRNA; Hydrogen Peroxide results in decreased expression of NFE2L2 proteinPMID:21573189 PMID:29274434 PMID:31521693
Nfe2l2decreases response to substanceISONFE2L2 (Homo sapiens)6480464CTDNFE2L2 protein results in decreased susceptibility to Hydrogen PeroxidePMID:17360324
Nfe2l2decreases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 results in decreased susceptibility to Hydrogen PeroxidePMID:18367636
Nfe2l2increases expressionISONFE2L2 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of NFE2L2 mRNA; Hydrogen Peroxide results in increased expression of NFE2L2 proteinPMID:23410634 PMID:29486183 PMID:32023790 PMID:33212048 PMID:35227738 PMID:36880193 PMID:37257343
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of NFE2L2 proteinPMID:29950142 PMID:31194955
Nfe2l2increases localizationISONFE2L2 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased localization of NFE2L2 proteinPMID:22021338
Nfe2l2multiple interactionsISONFE2L2 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]]; 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; [Arsenic results in increased abundance of Hydrogen Peroxide] which results in increased expression of and results in increased localization of NFE2L2 protein; [Arsenic results in increased abundance of Hydrogen Peroxide] which results in increased expression of NFE2L2 mRNA; [formononetin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 mRNA; [Hydrogen Peroxide co-treated with 4-((alpha-L-rhamnosyloxy)benzyl)isothiocyanate] results in increased expression of NFE2L2 protein; [Hydrogen Peroxide co-treated with loliolide] results in increased expression of NFE2L2 protein; [polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein; alpha-Tocopherol promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; Ascorbic Acid inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFE2L2 protein]; astaxanthine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]; brusatol inhibits the reaction [Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]]; CDKN1A protein affects the reaction [Hydrogen Peroxide results in increased expression of and affects the localization of NFE2L2 protein]; Curcumin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; dendrobine promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]; Hydrogen Peroxide promotes the reaction [MIR153 mRNA binds to NFE2L2 3' UTR]; Hydrogen Peroxide promotes the reaction [NFE2L2 protein binds to CDKN1A promoter]; Hydrogen Peroxide results in increased expression of and affects the localization of NFE2L2 protein; Hydrogen Peroxide results in increased expression of and results in increased phosphorylation of NFE2L2 protein; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]; NFE2L2 protein affects the reaction [[polydatin co-treated with Hydrogen Peroxide] results in increased expression of NFE2L2 protein]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CAT protein]]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein]]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]]; NFE2L2 protein affects the reaction [dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in decreased expression of CAT protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in decreased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in decreased expression of SOD2 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of ALDH2 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of AR protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of CDKN1A mRNA]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of CDKN1A protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of GCLM protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of TXNRD1 protein]; NFE2L2 protein affects the reaction [polydatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NQO1 protein]]; Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 mRNA]; Saponins inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]; swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]; swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Thioctic Acid promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; withanone inhibits the reaction [Hydrogen Peroxide results in decreased expression of NFE2L2 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]PMID:14567983 PMID:21573189 PMID:24866057 PMID:28285367 PMID:29274434 PMID:29486183 PMID:30231594 PMID:31521693 PMID:31705858 PMID:33212048 PMID:34077701 PMID:35227738 PMID:36058301 PMID:36880193
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD1,2-dithiol-3-thione promotes the reaction [NFE2L2 results in decreased susceptibility to Hydrogen Peroxide]; [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased oxidation of TXN1 protein]; [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] inhibits the reaction [Hydrogen Peroxide results in increased oxidation of TXN2 protein]; [1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Hydrogen Peroxide; BACH1 protein affects the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]; Hydrogen Peroxide promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Hydrogen Peroxide promotes the reaction [NFE2L2 protein binds to PSMB5 promoter]; Hydrogen Peroxide promotes the reaction [NFE2L2 protein binds to SULT1E1 promoter]; Hydrogen Peroxide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of LAMP2 protein alternative form]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of PSMB1 protein]; NFE2L2 protein affects the reaction [Hydrogen Peroxide results in increased expression of PSME1 protein]; SIRT6 protein affects the reaction [Hydrogen Peroxide affects the expression of NFE2L2 protein]; Tretinoin inhibits the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]PMID:18367636 PMID:22308036 PMID:22495766 PMID:25922074 PMID:29950142 PMID:31194955 PMID:36356655
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