GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp9 | increases activity | EXP | | 6480464 | CTD | Hydrogen Peroxide results in increased activity of CASP9 protein | PMID:14505808 PMID:16647178 | Casp9 | multiple interactions | EXP | | 6480464 | CTD | 3,4-dihydro-5-methyl-1(2H)-isoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; 3-aminobenzamide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; INO 1001 inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Niacinamide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein] | PMID:14505808 PMID:16505238 PMID:16647178 | Casp9 | affects expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide affects the expression of CASP9 protein | PMID:21179406 | Casp9 | increases activity | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased activity of CASP9 protein | PMID:14753751 PMID:21431366 PMID:27317026 PMID:28400100 PMID:31306736 | Casp9 | increases cleavage | ISO | Casp9 (Mus musculus) | 6480464 | CTD | Hydrogen Peroxide results in increased cleavage of CASP9 protein | PMID:12626342 PMID:15876423 PMID:20878536 | Casp9 | increases cleavage | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased cleavage of CASP9 protein | PMID:25005833 PMID:25108166 PMID:29902531 PMID:30404999 PMID:35202708 | Casp9 | increases expression | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | Hydrogen Peroxide results in increased expression of CASP9 mRNA; Hydrogen Peroxide results in increased expression of CASP9 protein | PMID:20361964 PMID:26164594 PMID:29274434 PMID:33709623 PMID:36058301 PMID:37648050 | Casp9 | multiple interactions | ISO | Casp9 (Mus musculus) | 6480464 | CTD | PARP1 protein promotes the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein] | PMID:15876423 PMID:20878536 | Casp9 | multiple interactions | ISO | CASP9 (Homo sapiens) | 6480464 | CTD | [sodium cyanate co-treated with Hydrogen Peroxide] results in increased activity of CASP9 protein; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; Aspirin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; dendrobine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; EUK-134 inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; HGF protein inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; homoeriodictyol inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Hydrogen Peroxide results in decreased expression of and results in increased cleavage of CASP9 protein; kahweol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; kukoamine B inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; Melatonin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Melatonin promotes the reaction [Hydrogen Peroxide results in increased activity of CASP9 protein]; Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP9 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 mRNA]; Saponins inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP9 mRNA] | PMID:14753751 PMID:20361964 PMID:21431366 PMID:25005833 PMID:25108166 PMID:26164594 PMID:28400100 PMID:29274434 PMID:29902531 PMID:30404999 PMID:31306736 PMID:31313457 PMID:36058301 PMID:37648050 | | ||||||||||||||||||||||
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