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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3880
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Faslg
Name: Fas ligand
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faslgincreases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of FASLG proteinPMID:15799720
Faslgmultiple interactionsEXP 6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Hydrogen Peroxide results in increased expression of FASLG protein]; [mitoquinol co-treated with mitoquinone] inhibits the reaction [Hydrogen Peroxide results in increased expression of FASL protein]PMID:15799720
Faslgincreases chemical synthesisISOFASLG (Homo sapiens)6480464CTDFASL protein results in increased chemical synthesis of Hydrogen PeroxidePMID:17724027
Faslgincreases expressionISOFasl (Mus musculus)6480464CTDHydrogen Peroxide results in increased expression of FASL mRNA; Hydrogen Peroxide results in increased expression of FASL proteinPMID:9657385
Faslgincreases expressionISOFASLG (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of FASLG mRNAPMID:21347231
Faslgmultiple interactionsISOFASLG (Homo sapiens)6480464CTD[Clozapine analog co-treated with Hydrogen Peroxide] results in increased expression of FASLG mRNA; [Clozapine co-treated with Hydrogen Peroxide co-treated with Tretinoin] results in increased expression of FASLG mRNA; Pyruvic Acid inhibits the reaction [FASL protein results in increased chemical synthesis of Hydrogen Peroxide]PMID:16510162 PMID:17724027
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