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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2993
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lcat
Name: lecithin cholesterol acyltransferase
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lcatdecreases expressionISOLCAT (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of LCAT mRNAPMID:12419474
Lcatmultiple interactionsISOLCAT (Homo sapiens)6480464CTD[[MPO protein co-treated with Hydrogen Peroxide co-treated with Sodium Chloride] results in increased oxidation of APOA1 protein] which results in decreased activity of LCAT proteinPMID:33861588
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