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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2200
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bcl2l1
Name: Bcl2-like 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l1decreases expressionEXP 6480464CTDHydrogen Peroxide results in decreased expression of BCL2L1 mRNA; Hydrogen Peroxide results in decreased expression of BCL2L1 proteinPMID:14505808 PMID:25726415
Bcl2l1decreases response to substanceEXP 6480464CTDBCL2L1 gene mutant form results in decreased susceptibility to Hydrogen PeroxidePMID:10970895
Bcl2l1increases expressionEXP 6480464CTDHydrogen Peroxide results in increased expression of BCL2L1 mRNAPMID:14689451
Bcl2l1multiple interactionsEXP 6480464CTDGATA5 protein promotes the reaction [Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]]; Nitric Oxide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]PMID:14505808 PMID:25726415
Bcl2l1affects expressionISOBCL2L1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the expression of BCL2L1 proteinPMID:21179406 PMID:29902531
Bcl2l1decreases expressionISOBCL2L1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased expression of BCL2L1 proteinPMID:15703382 PMID:22269385 PMID:31313457
Bcl2l1multiple interactionsISOBCL2L1 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; CYP26A1 protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; CYP26A1 protein inhibits the reaction [Tretinoin promotes the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]]; HGF protein inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; homoeriodictyol inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2L1 protein]; Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]; Tretinoin promotes the reaction [Hydrogen Peroxide results in decreased expression of BCL2L1 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]]PMID:15142122 PMID:15703382 PMID:29902531 PMID:31313457
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