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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323582
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPM2
Name: transient receptor potential cation channel subfamily M member 2
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPM2increases activityEXP 6480464CTDHydrogen Peroxide results in increased activity of TRPM2 proteinPMID:29658714 PMID:30229906
TRPM2increases response to substanceEXP 6480464CTDTRPM2 protein results in increased susceptibility to Hydrogen PeroxidePMID:29658714 PMID:30625984
TRPM2multiple interactionsISOTrpm2 (Rattus norvegicus)6480464CTD[Paraquat results in increased expression of Hydrogen Peroxide] which results in increased activity of TRPM2 protein; Calcium affects the reaction [Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]]; Hydrogen Peroxide promotes the reaction [TRPM2 protein results in increased transport of Calcium]PMID:21900507 PMID:35339517
TRPM2multiple interactionsISOTrpm2 (Mus musculus)6480464CTDTRPM2 protein promotes the reaction [Hydrogen Peroxide results in increased uptake of Calcium]PMID:20878536
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