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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730946 Species: Homo sapiens RGD Object: Gene Symbol: CRH Name: corticotropin releasing hormone

Acc ID: CHEBI:16236 Term: ethanol Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group. CasRN: 64-17-5 Chemical ID: MESH:D000431

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:620505	6480464	CTD	Ethanol affects the expression of CRH mRNA	PMID:18819432
multiple interactions	ISO	RGD:620505	6480464	CTD	[Ethanol co-treated with Cyanamide] results in increased expression of CRH mRNA	PMID:11139417
increases expression	ISO	RGD:620505	6480464	CTD	Ethanol results in increased expression of CRH mRNA	PMID:16925589
increases expression	ISO	RGD:730947	6480464	CTD	Ethanol results in increased expression of CRH mRNA	PMID:21955143
multiple interactions	ISO	RGD:620505	6480464	CTD	[Cholesterol, Dietary co-treated with Ethanol] results in decreased expression of CRH mRNA Estradiol inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	PMID:22384198
increases expression	ISO	RGD:620505	6480464	CTD	Ethanol results in increased expression of CRH mRNA	PMID:16925589 PMID:21533237 PMID:22039522 PMID:22384198
multiple interactions	ISO	RGD:620505	6480464	CTD	Mifepristone inhibits the reaction [Ethanol results in increased expression of CRH mRNA]	PMID:22039522
decreases expression	ISO	RGD:620505	6480464	CTD	Ethanol results in decreased expression of CRH mRNA	PMID:22039522